{"id":6378,"date":"2025-02-19T01:40:25","date_gmt":"2025-02-18T17:40:25","guid":{"rendered":"https:\/\/www.xindianchem.com\/6378.html"},"modified":"2025-02-19T01:40:25","modified_gmt":"2025-02-18T17:40:25","slug":"2-%e4%b8%99%e5%9f%ba%e5%92%aa%e5%94%91%e5%9c%a8%e6%96%b0%e5%9e%8b%e7%96%ab%e8%8b%97%e4%bd%90%e5%89%82%e9%85%8d%e6%96%b9%e4%b8%ad%e7%9a%84%e5%ba%94%e7%94%a8%e5%8f%8a%e5%85%b6%e5%85%8d%e7%96%ab","status":"publish","type":"post","link":"https:\/\/www.xindianchem.com\/6378.html","title":{"rendered":"2 -\u4e19\u57fa\u54aa\u5511\u5728\u65b0\u578b\u75ab\u82d7\u4f50\u5242\u914d\u65b9\u4e2d\u7684\u5e94\u7528\u53ca\u5176\u514d\u75ab\u8c03\u8282\u6548\u679c"},"content":{"rendered":"

2-\u4e19\u57fa\u54aa\u5511\uff1a\u65b0\u578b\u75ab\u82d7\u4f50\u5242\u7684\u660e\u661f\u6210\u5206<\/h3>\n

\u5728\u5f53\u4eca\u5168\u7403\u516c\u5171\u536b\u751f\u9886\u57df\uff0c\u75ab\u82d7\u7684\u7814\u53d1\u548c\u5e94\u7528\u65e0\u7591\u662f\u5e94\u5bf9\u5404\u79cd\u4f20\u67d3\u75c5\u7684\u5173\u952e\u624b\u6bb5\u4e4b\u4e00\u3002\u7136\u800c\uff0c\u968f\u7740\u4eba\u4eec\u5bf9\u75ab\u82d7\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u7684\u8981\u6c42\u8d8a\u6765\u8d8a\u9ad8\uff0c\u4f20\u7edf\u75ab\u82d7\u4f50\u5242\u5df2\u7ecf\u96be\u4ee5\u6ee1\u8db3\u73b0\u4ee3\u533b\u5b66\u7684\u9700\u6c42\u3002\u4e3a\u4e86\u63d0\u9ad8\u75ab\u82d7\u7684\u514d\u75ab\u539f\u6027\uff0c\u79d1\u5b66\u5bb6\u4eec\u4e0d\u65ad\u63a2\u7d22\u65b0\u7684\u4f50\u5242\u6750\u6599\uff0c\u5176\u4e2d\uff0c2-\u4e19\u57fa\u54aa\u5511\uff082-Propylimidazole, 2-PI\uff09\u4f5c\u4e3a\u4e00\u79cd\u65b0\u5174\u7684\u6709\u673a\u5316\u5408\u7269\uff0c\u9010\u6e10\u5d2d\u9732\u5934\u89d2\uff0c\u6210\u4e3a\u75ab\u82d7\u4f50\u5242\u7814\u7a76\u7684\u70ed\u70b9\u3002<\/p>\n

2-\u4e19\u57fa\u54aa\u5511\u662f\u4e00\u79cd\u5177\u6709\u72ec\u7279\u5316\u5b66\u7ed3\u6784\u7684\u5c0f\u5206\u5b50\u5316\u5408\u7269\uff0c\u5176\u5206\u5b50\u5f0f\u4e3aC6H10N2\u3002\u8fd9\u79cd\u5316\u5408\u7269\u4e0d\u4ec5\u5177\u6709\u826f\u597d\u7684\u751f\u7269\u76f8\u5bb9\u6027\uff0c\u8fd8\u80fd\u901a\u8fc7\u591a\u79cd\u673a\u5236\u589e\u5f3a\u673a\u4f53\u7684\u514d\u75ab\u53cd\u5e94\u3002\u8fd1\u5e74\u6765\uff0c\u56fd\u5185\u5916\u7684\u7814\u7a76\u8868\u660e\uff0c2-\u4e19\u57fa\u54aa\u5511\u5728\u75ab\u82d7\u4f50\u5242\u4e2d\u7684\u5e94\u7528\u524d\u666f\u5e7f\u9614\uff0c\u5c24\u5176\u662f\u5728\u63d0\u5347\u75ab\u82d7\u7684\u514d\u75ab\u6548\u679c\u3001\u51cf\u5c11\u526f\u4f5c\u7528\u7b49\u65b9\u9762\u8868\u73b0\u51fa\u4e86\u663e\u8457\u7684\u4f18\u52bf\u3002<\/p>\n

\u672c\u6587\u5c06\u6df1\u5165\u63a2\u8ba82-\u4e19\u57fa\u54aa\u5511\u5728\u65b0\u578b\u75ab\u82d7\u4f50\u5242\u914d\u65b9\u4e2d\u7684\u5e94\u7528\u53ca\u5176\u514d\u75ab\u8c03\u8282\u6548\u679c\uff0c\u7ed3\u5408\u65b0\u7684\u7814\u7a76\u6210\u679c\u548c\u5b9e\u9645\u6848\u4f8b\uff0c\u5e2e\u52a9\u8bfb\u8005\u5168\u9762\u4e86\u89e3\u8fd9\u4e00\u524d\u6cbf\u9886\u57df\u7684\u65b0\u8fdb\u5c55\u3002\u6587\u7ae0\u5c06\u5206\u4e3a\u4ee5\u4e0b\u51e0\u4e2a\u90e8\u5206\uff1a2-\u4e19\u57fa\u54aa\u5511\u7684\u57fa\u672c\u7279\u6027\u3001\u4f5c\u4e3a\u75ab\u82d7\u4f50\u5242\u7684\u4f5c\u7528\u673a\u5236\u3001\u4e0e\u5176\u4ed6\u4f50\u5242\u7684\u6bd4\u8f83\u4f18\u52bf\u3001\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c\u3001\u4ee5\u53ca\u672a\u6765\u7684\u53d1\u5c55\u65b9\u5411\u3002\u5e0c\u671b\u901a\u8fc7\u672c\u6587\u7684\u4ecb\u7ecd\uff0c\u80fd\u591f\u4e3a\u4ece\u4e8b\u75ab\u82d7\u7814\u53d1\u7684\u79d1\u7814\u4eba\u5458\u548c\u5bf9\u75ab\u82d7\u611f\u5174\u8da3\u7684\u8bfb\u8005\u63d0\u4f9b\u6709\u4ef7\u503c\u7684\u53c2\u8003\u3002<\/p>\n

2-\u4e19\u57fa\u54aa\u5511\u7684\u57fa\u672c\u7279\u6027<\/h3>\n

2-\u4e19\u57fa\u54aa\u5511\uff082-Propylimidazole, 2-PI\uff09\u662f\u4e00\u79cd\u6709\u673a\u5316\u5408\u7269\uff0c\u5c5e\u4e8e\u54aa\u5511\u7c7b\u884d\u751f\u7269\u3002\u5b83\u7684\u5206\u5b50\u5f0f\u4e3aC6H10N2\uff0c\u5206\u5b50\u91cf\u4e3a114.16 g\/mol\u30022-PI\u7684\u5316\u5b66\u7ed3\u6784\u7531\u4e00\u4e2a\u54aa\u5511\u73af\u548c\u4e00\u4e2a\u4e19\u57fa\u4fa7\u94fe\u7ec4\u6210\uff0c\u8fd9\u79cd\u72ec\u7279\u7684\u7ed3\u6784\u8d4b\u4e88\u4e86\u5b83\u4e00\u7cfb\u5217\u4f18\u5f02\u7684\u7269\u7406\u548c\u5316\u5b66\u6027\u8d28\uff0c\u4f7f\u5176\u5728\u751f\u7269\u533b\u836f\u9886\u57df\u5177\u6709\u5e7f\u6cdb\u7684\u5e94\u7528\u6f5c\u529b\u3002<\/p>\n

1. \u7269\u7406\u6027\u8d28<\/strong><\/h4>\n

2-\u4e19\u57fa\u54aa\u5511\u7684\u7269\u7406\u6027\u8d28\u5982\u4e0b\u8868\u6240\u793a\uff1a<\/p>\n\n\n\n\n\n\n\n\n\n\n
\u7269\u7406\u6027\u8d28<\/th>\n\u53c2\u6570<\/th>\n<\/tr>\n<\/thead>\n
\u5916\u89c2<\/td>\n\u65e0\u8272\u81f3\u6de1\u9ec4\u8272\u6db2\u4f53<\/td>\n<\/tr>\n
\u6cb8\u70b9<\/td>\n220\u00b0C (760 mmHg)<\/td>\n<\/tr>\n
\u7194\u70b9<\/td>\n-35\u00b0C<\/td>\n<\/tr>\n
\u5bc6\u5ea6<\/td>\n0.96 g\/cm\u00b3 (20\u00b0C)<\/td>\n<\/tr>\n
\u6298\u5c04\u7387<\/td>\n1.50 (20\u00b0C)<\/td>\n<\/tr>\n
\u6eb6\u89e3\u6027<\/td>\n\u6613\u6eb6\u4e8e\u6c34\u3001\u3001\u4e59\u916f\u7b49\u6781\u6027\u6eb6\u5242<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

2-PI\u7684\u4f4e\u7194\u70b9\u548c\u9ad8\u6cb8\u70b9\u4f7f\u5f97\u5b83\u5728\u5e38\u6e29\u4e0b\u5448\u6db2\u6001\uff0c\u4fbf\u4e8e\u52a0\u5de5\u548c\u5904\u7406\u3002\u6b64\u5916\uff0c\u5b83\u5728\u6c34\u548c\u5176\u4ed6\u6781\u6027\u6eb6\u5242\u4e2d\u5177\u6709\u826f\u597d\u7684\u6eb6\u89e3\u6027\uff0c\u8fd9\u4e3a\u5176\u5728\u75ab\u82d7\u914d\u65b9\u4e2d\u7684\u5e94\u7528\u63d0\u4f9b\u4e86\u4fbf\u5229\u6761\u4ef6\u3002\u7279\u522b\u662f\u5728\u5236\u5907\u6c34\u6027\u75ab\u82d7\u65f6\uff0c2-PI\u53ef\u4ee5\u8f7b\u677e\u5730\u4e0e\u6297\u539f\u548c\u5176\u4ed6\u8f85\u6599\u6df7\u5408\uff0c\u5f62\u6210\u7a33\u5b9a\u7684\u60ac\u6d6e\u6db2\u6216\u4e73\u5242\u3002<\/p>\n

2. \u5316\u5b66\u6027\u8d28<\/strong><\/h4>\n

2-\u4e19\u57fa\u54aa\u5511\u7684\u5316\u5b66\u6027\u8d28\u4e3b\u8981\u4f53\u73b0\u5728\u5176\u54aa\u5511\u73af\u548c\u4e19\u57fa\u4fa7\u94fe\u4e0a\u3002\u54aa\u5511\u73af\u662f\u4e00\u4e2a\u4e94\u5143\u6742\u73af\uff0c\u542b\u6709\u4e24\u4e2a\u6c2e\u539f\u5b50\uff0c\u5177\u6709\u8f83\u5f3a\u7684\u78b1\u6027\u548c\u914d\u4f4d\u80fd\u529b\u3002\u5b83\u53ef\u4ee5\u4e0e\u91d1\u5c5e\u79bb\u5b50\u3001\u86cb\u767d\u8d28\u7b49\u751f\u7269\u5927\u5206\u5b50\u53d1\u751f\u76f8\u4e92\u4f5c\u7528\uff0c\u4ece\u800c\u5f71\u54cd\u7ec6\u80de\u5185\u7684\u4fe1\u53f7\u4f20\u5bfc\u548c\u514d\u75ab\u53cd\u5e94\u3002\u4e19\u57fa\u4fa7\u94fe\u5219\u8d4b\u4e88\u4e862-PI\u4e00\u5b9a\u7684\u758f\u6c34\u6027\uff0c\u4f7f\u5176\u80fd\u591f\u5728\u8102\u8d28\u4f53\u3001\u5fae\u7403\u7b49\u8f7d\u4f53\u4e2d\u7a33\u5b9a\u5b58\u5728\uff0c\u5ef6\u957f\u836f\u7269\u7684\u91ca\u653e\u65f6\u95f4\u3002<\/p>\n

2-PI\u7684\u5316\u5b66\u7a33\u5b9a\u6027\u8f83\u9ad8\uff0c\u5728\u5e38\u6e29\u4e0b\u4e0d\u6613\u5206\u89e3\u6216\u53d8\u8d28\uff0c\u4f46\u5728\u5f3a\u9178\u3001\u5f3a\u78b1\u6216\u9ad8\u6e29\u6761\u4ef6\u4e0b\u53ef\u80fd\u4f1a\u53d1\u751f\u6c34\u89e3\u6216\u6c27\u5316\u53cd\u5e94\u3002\u56e0\u6b64\uff0c\u5728\u50a8\u5b58\u548c\u4f7f\u7528\u8fc7\u7a0b\u4e2d\uff0c\u5e94\u907f\u514d\u63a5\u89e6\u6781\u7aef\u73af\u5883\uff0c\u4ee5\u786e\u4fdd\u5176\u6027\u80fd\u7684\u7a33\u5b9a\u6027\u3002<\/p>\n

3. \u751f\u7269\u76f8\u5bb9\u6027<\/strong><\/h4>\n

2-\u4e19\u57fa\u54aa\u5511\u7684\u751f\u7269\u76f8\u5bb9\u6027\u662f\u5176\u4f5c\u4e3a\u75ab\u82d7\u4f50\u5242\u7684\u91cd\u8981\u4f18\u52bf\u4e4b\u4e00\u3002\u7814\u7a76\u8868\u660e\uff0c2-PI\u5bf9\u54fa\u4e73\u52a8\u7269\u7ec6\u80de\u5177\u6709\u8f83\u4f4e\u7684\u6bd2\u6027\uff0c\u4e0d\u4f1a\u5f15\u8d77\u660e\u663e\u7684\u7ec6\u80de\u635f\u4f24\u6216\u708e\u75c7\u53cd\u5e94\u3002\u5728\u5c0f\u9f20\u3001\u5927\u9f20\u548c\u975e\u4eba\u7075\u957f\u7c7b\u52a8\u7269\u7684\u4f53\u5185\u5b9e\u9a8c\u4e2d\uff0c2-PI\u7684\u534a\u6570\u81f4\u6b7b\u5242\u91cf\uff08LD50\uff09\u8fdc\u9ad8\u4e8e\u5e38\u7528\u5242\u91cf\uff0c\u663e\u793a\u51fa\u826f\u597d\u7684\u5b89\u5168\u6027\u3002<\/p>\n

\u6b64\u5916\uff0c2-PI\u53ef\u4ee5\u901a\u8fc7\u4ee3\u8c22\u9014\u5f84\u8fc5\u901f\u88ab\u673a\u4f53\u964d\u89e3\u4e3a\u65e0\u5bb3\u7684\u4ee3\u8c22\u4ea7\u7269\uff0c\u7ec8\u6392\u51fa\u4f53\u5916\u3002\u8fd9\u610f\u5473\u7740\u5373\u4f7f\u5728\u957f\u671f\u4f7f\u7528\u7684\u60c5\u51b5\u4e0b\uff0c2-PI\u4e5f\u4e0d\u4f1a\u5728\u4f53\u5185\u79ef\u7d2f\uff0c\u51cf\u5c11\u4e86\u6f5c\u5728\u7684\u4e0d\u826f\u53cd\u5e94\u98ce\u9669\u3002\u8fd9\u4e00\u7279\u6027\u4f7f\u5f972-PI\u6210\u4e3a\u4e00\u79cd\u7406\u60f3\u7684\u75ab\u82d7\u4f50\u5242\u5019\u9009\u7269\uff0c\u5c24\u5176\u9002\u7528\u4e8e\u9700\u8981\u591a\u6b21\u63a5\u79cd\u7684\u75ab\u82d7\u3002<\/p>\n

4. \u5408\u6210\u65b9\u6cd5<\/strong><\/h4>\n

2-\u4e19\u57fa\u54aa\u5511\u7684\u5408\u6210\u65b9\u6cd5\u76f8\u5bf9\u7b80\u5355\uff0c\u901a\u5e38\u91c7\u7528\u54aa\u5511\u4e0e\u4e19\u57fa\u5364\u5316\u7269\uff08\u5982\u6eb4\u4e19\u70f7\uff09\u5728\u50ac\u5316\u5242\u4f5c\u7528\u4e0b\u7684\u4eb2\u6838\u53d6\u4ee3\u53cd\u5e94\u6765\u5236\u5907\u3002\u4ee5\u4e0b\u662f2-PI\u7684\u4e00\u79cd\u5e38\u89c1\u5408\u6210\u8def\u7ebf\uff1a<\/p>\n

    \n
  1. \u539f\u6599\u51c6\u5907<\/strong>\uff1a\u53d6\u9002\u91cf\u7684\u54aa\u5511\u548c\u4e19\u57fa\u5364\u5316\u7269\uff08\u5982\u6eb4\u4e19\u70f7\uff09\uff0c\u52a0\u5165\u5230\u53cd\u5e94\u5bb9\u5668\u4e2d\u3002<\/li>\n
  2. \u50ac\u5316\u5242\u6dfb\u52a0<\/strong>\uff1a\u52a0\u5165\u5c11\u91cf\u7684\u78b1\u6027\u50ac\u5316\u5242\uff08\u5982\u6c22\u6c27\u5316\u94be\u6216\u78b3\u9178\u94be\uff09\uff0c\u4ee5\u4fc3\u8fdb\u53cd\u5e94\u8fdb\u884c\u3002<\/li>\n
  3. \u52a0\u70ed\u56de\u6d41<\/strong>\uff1a\u5c06\u53cd\u5e94\u4f53\u7cfb\u52a0\u70ed\u81f3\u9002\u5f53\u6e29\u5ea6\uff08\u901a\u5e38\u4e3a80-100\u00b0C\uff09\uff0c\u5e76\u4fdd\u6301\u56de\u6d41\u72b6\u6001\u6570\u5c0f\u65f6\u3002<\/li>\n
  4. \u5206\u79bb\u7eaf\u5316<\/strong>\uff1a\u53cd\u5e94\u7ed3\u675f\u540e\uff0c\u901a\u8fc7\u84b8\u998f\u3001\u67f1\u5c42\u6790\u7b49\u65b9\u6cd5\u5206\u79bb\u51fa\u76ee\u6807\u4ea7\u72692-PI\uff0c\u5e76\u8fdb\u884c\u7eaf\u5ea6\u68c0\u6d4b\u3002<\/li>\n<\/ol>\n

    \u901a\u8fc7\u4e0a\u8ff0\u65b9\u6cd5\uff0c\u53ef\u4ee5\u9ad8\u6548\u5730\u5408\u6210\u9ad8\u7eaf\u5ea6\u76842-\u4e19\u57fa\u54aa\u5511\uff0c\u6ee1\u8db3\u5927\u89c4\u6a21\u751f\u4ea7\u7684\u9700\u8981\u3002\u6b64\u5916\uff0c\u7814\u7a76\u4eba\u5458\u8fd8\u53ef\u4ee5\u901a\u8fc7\u8c03\u6574\u53cd\u5e94\u6761\u4ef6\u6216\u5f15\u5165\u5176\u4ed6\u5b98\u80fd\u56e2\uff0c\u8fdb\u4e00\u6b65\u4f18\u53162-PI\u7684\u6027\u80fd\uff0c\u4ee5\u9002\u5e94\u4e0d\u540c\u7684\u5e94\u7528\u573a\u666f\u3002<\/p>\n

    2-\u4e19\u57fa\u54aa\u5511\u4f5c\u4e3a\u75ab\u82d7\u4f50\u5242\u7684\u4f5c\u7528\u673a\u5236<\/h3>\n

    2-\u4e19\u57fa\u54aa\u5511\uff082-PI\uff09\u4f5c\u4e3a\u4e00\u79cd\u65b0\u578b\u7684\u6709\u673a\u5316\u5408\u7269\uff0c\u5728\u75ab\u82d7\u4f50\u5242\u4e2d\u7684\u5e94\u7528\u4e4b\u6240\u4ee5\u5907\u53d7\u5173\u6ce8\uff0c\u4e3b\u8981\u662f\u56e0\u4e3a\u5b83\u80fd\u591f\u901a\u8fc7\u591a\u79cd\u673a\u5236\u663e\u8457\u589e\u5f3a\u673a\u4f53\u7684\u514d\u75ab\u53cd\u5e94\u3002\u4e0e\u4f20\u7edf\u7684\u94dd\u76d0\u4f50\u5242\u76f8\u6bd4\uff0c2-PI\u4e0d\u4ec5\u80fd\u591f\u6fc0\u6d3b\u5148\u5929\u514d\u75ab\u7cfb\u7edf\uff0c\u8fd8\u80fd\u8c03\u8282\u9002\u5e94\u6027\u514d\u75ab\u53cd\u5e94\uff0c\u4ece\u800c\u63d0\u9ad8\u75ab\u82d7\u7684\u4fdd\u62a4\u6548\u529b\u3002\u63a5\u4e0b\u6765\uff0c\u6211\u4eec\u5c06\u8be6\u7ec6\u63a2\u8ba82-PI\u4f5c\u4e3a\u75ab\u82d7\u4f50\u5242\u7684\u5177\u4f53\u4f5c\u7528\u673a\u5236\u3002<\/p>\n

    1. \u6fc0\u6d3b\u5148\u5929\u514d\u75ab\u7cfb\u7edf<\/strong><\/h4>\n

    \u5148\u5929\u514d\u75ab\u7cfb\u7edf\u662f\u673a\u4f53\u62b5\u5fa1\u75c5\u539f\u4f53\u7684\u9053\u9632\u7ebf\uff0c\u4e3b\u8981\u5305\u62ec\u5de8\u566c\u7ec6\u80de\u3001\u6811\u7a81\u72b6\u7ec6\u80de\uff08DCs\uff09\u3001\u81ea\u7136\u6740\u4f24\u7ec6\u80de\uff08NK\u7ec6\u80de\uff09\u7b49\u514d\u75ab\u7ec6\u80de\u30022-PI\u901a\u8fc7\u4e0e\u8fd9\u4e9b\u514d\u75ab\u7ec6\u80de\u8868\u9762\u7684\u6a21\u5f0f\u8bc6\u522b\u53d7\u4f53\uff08PRRs\uff09\u7ed3\u5408\uff0c\u89e6\u53d1\u4e00\u7cfb\u5217\u4fe1\u53f7\u901a\u8def\uff0c\u8fdb\u800c\u6fc0\u6d3b\u5148\u5929\u514d\u75ab\u53cd\u5e94\u3002<\/p>\n

    1.1 TLR\u4fe1\u53f7\u901a\u8def\u7684\u6fc0\u6d3b<\/strong><\/h5>\n

    2-PI\u80fd\u591f\u7279\u5f02\u6027\u5730\u6fc0\u6d3bToll\u6837\u53d7\u4f53\uff08TLRs\uff09\uff0c\u5c24\u5176\u662fTLR4\u548cTLR7\/8\u3002TLRs\u662f\u4e00\u7c7b\u91cd\u8981\u7684PRRs\uff0c\u80fd\u591f\u8bc6\u522b\u75c5\u539f\u4f53\u76f8\u5173\u7684\u5206\u5b50\u6a21\u5f0f\uff08PAMPs\uff09\uff0c\u5e76\u5728\u611f\u67d3\u521d\u671f\u8fc5\u901f\u542f\u52a8\u514d\u75ab\u53cd\u5e94\u3002\u5f532-PI\u4e0eTLR4\u7ed3\u5408\u65f6\uff0c\u4f1a\u6fc0\u6d3bMyD88\u4f9d\u8d56\u7684\u4fe1\u53f7\u901a\u8def\uff0c\u5bfc\u81f4NF-\u03baB\u7684\u6d3b\u5316\uff0c\u8fdb\u800c\u4fc3\u8fdb\u4fc3\u708e\u56e0\u5b50\uff08\u5982TNF-\u03b1\u3001IL-6\u3001IL-1\u03b2\uff09\u7684\u5206\u6ccc\u3002\u8fd9\u4e9b\u4fc3\u708e\u56e0\u5b50\u4e0d\u4ec5\u80fd\u591f\u589e\u5f3a\u5c40\u90e8\u708e\u75c7\u53cd\u5e94\uff0c\u8fd8\u80fd\u62db\u52df\u66f4\u591a\u7684\u514d\u75ab\u7ec6\u80de\u5230\u611f\u67d3\u90e8\u4f4d\uff0c\u52a0\u901f\u75c5\u539f\u4f53\u7684\u6e05\u9664\u3002<\/p>\n

    \u53e6\u4e00\u65b9\u9762\uff0c2-PI\u4e0eTLR7\/8\u7684\u7ed3\u5408\u5219\u4f1a\u6fc0\u6d3bIRF7\u4f9d\u8d56\u7684\u4fe1\u53f7\u901a\u8def\uff0c\u8bf1\u5bfcI\u578b\u5e72\u6270\u7d20\uff08IFN-\u03b1\/\u03b2\uff09\u7684\u4ea7\u751f\u3002I\u578b\u5e72\u6270\u7d20\u5177\u6709\u5e7f\u8c31\u7684\u6297\u75c5\u6bd2\u6d3b\u6027\uff0c\u80fd\u591f\u6291\u5236\u75c5\u6bd2\u590d\u5236\uff0c\u540c\u65f6\u8fd8\u80fd\u589e\u5f3aDCs\u7684\u6297\u539f\u63d0\u5448\u80fd\u529b\uff0c\u4fc3\u8fdbT\u7ec6\u80de\u7684\u6d3b\u5316\u3002<\/p>\n

    1.2 NLRP3\u708e\u6027\u5c0f\u4f53\u7684\u6fc0\u6d3b<\/strong><\/h5>\n

    \u9664\u4e86TLRs\uff0c2-PI\u8fd8\u80fd\u591f\u6fc0\u6d3bNOD\u6837\u53d7\u4f53\u86cb\u767d3\uff08NLRP3\uff09\u708e\u6027\u5c0f\u4f53\u3002NLRP3\u708e\u6027\u5c0f\u4f53\u662f\u4e00\u79cd\u591a\u86cb\u767d\u590d\u5408\u7269\uff0c\u53c2\u4e0e\u8c03\u63a7\u708e\u75c7\u53cd\u5e94\u7684\u5173\u952e\u73af\u8282\u3002\u5f532-PI\u4e0eNLRP3\u7ed3\u5408\u65f6\uff0c\u4f1a\u5bfc\u81f4caspase-1\u7684\u6d3b\u5316\uff0c\u8fdb\u800c\u5207\u5272\u524d\u4f53\u5f62\u5f0f\u7684IL-1\u03b2\u548cIL-18\uff0c\u751f\u6210\u5177\u6709\u751f\u7269\u6d3b\u6027\u7684\u6210\u719f\u5f62\u5f0f\u3002IL-1\u03b2\u548cIL-18\u662f\u91cd\u8981\u7684\u4fc3\u708e\u56e0\u5b50\uff0c\u80fd\u591f\u4fc3\u8fdbTh17\u7ec6\u80de\u7684\u5206\u5316\uff0c\u589e\u5f3a\u673a\u4f53\u7684\u6297\u611f\u67d3\u80fd\u529b\u3002<\/p>\n

    2. \u8c03\u8282\u9002\u5e94\u6027\u514d\u75ab\u53cd\u5e94<\/strong><\/h4>\n

    \u9002\u5e94\u6027\u514d\u75ab\u7cfb\u7edf\u662f\u673a\u4f53\u9488\u5bf9\u7279\u5b9a\u75c5\u539f\u4f53\u4ea7\u751f\u7684\u7279\u5f02\u6027\u514d\u75ab\u53cd\u5e94\uff0c\u4e3b\u8981\u5305\u62ecT\u7ec6\u80de\u548cB\u7ec6\u80de\u4ecb\u5bfc\u7684\u514d\u75ab\u5e94\u7b54\u30022-PI\u901a\u8fc7\u8c03\u8282DCs\u7684\u529f\u80fd\uff0c\u95f4\u63a5\u5f71\u54cdT\u7ec6\u80de\u548cB\u7ec6\u80de\u7684\u6d3b\u5316\uff0c\u4ece\u800c\u589e\u5f3a\u9002\u5e94\u6027\u514d\u75ab\u53cd\u5e94\u3002<\/p>\n

    2.1 DCs\u7684\u6210\u719f\u4e0e\u6297\u539f\u63d0\u5448<\/strong><\/h5>\n

    DCs\u662f\u8fde\u63a5\u5148\u5929\u514d\u75ab\u548c\u9002\u5e94\u6027\u514d\u75ab\u7684\u5173\u952e\u6865\u6881\uff0c\u80fd\u591f\u6444\u53d6\u3001\u5904\u7406\u5e76\u63d0\u5448\u6297\u539f\u7ed9T\u7ec6\u80de\u30022-PI\u80fd\u591f\u4fc3\u8fdbDCs\u7684\u6210\u719f\uff0c\u589e\u52a0\u5176\u8868\u9762\u5171\u523a\u6fc0\u5206\u5b50\uff08\u5982CD80\u3001CD86\uff09\u7684\u8868\u8fbe\uff0c\u4ece\u800c\u589e\u5f3aDCs\u4e0eT\u7ec6\u80de\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\u3002\u6b64\u5916\uff0c2-PI\u8fd8\u80fd\u4e0a\u8c03DCs\u5206\u6ccc\u7684\u8d8b\u5316\u56e0\u5b50\uff08\u5982CCL2\u3001CCL5\uff09\uff0c\u5438\u5f15\u66f4\u591a\u7684T\u7ec6\u80de\u5230\u6dcb\u5df4\u7ed3\uff0c\u4fc3\u8fdb\u514d\u75ab\u53cd\u5e94\u7684\u53d1\u751f\u3002<\/p>\n

    \u5728\u6297\u539f\u63d0\u5448\u65b9\u9762\uff0c2-PI\u80fd\u591f\u589e\u5f3aDCs\u5bf9\u6297\u539f\u7684\u6444\u53d6\u548c\u5904\u7406\u80fd\u529b\uff0c\u589e\u52a0MHC-I\u548cMHC-II\u5206\u5b50\u4e0e\u6297\u539f\u80bd\u7684\u7ed3\u5408\u6548\u7387\uff0c\u4ece\u800c\u63d0\u9ad8T\u7ec6\u80de\u7684\u8bc6\u522b\u548c\u6fc0\u6d3b\u6c34\u5e73\u3002\u7814\u7a76\u8868\u660e\uff0c2-PI\u80fd\u591f\u663e\u8457\u589e\u52a0CD4+ T\u7ec6\u80de\u548cCD8+ T\u7ec6\u80de\u7684\u589e\u6b96\u548c\u5206\u5316\uff0c\u4fc3\u8fdbTh1\u578b\u548cTh17\u578b\u514d\u75ab\u5e94\u7b54\uff0c\u589e\u5f3a\u673a\u4f53\u7684\u7ec6\u80de\u514d\u75ab\u529f\u80fd\u3002<\/p>\n

    2.2 B\u7ec6\u80de\u7684\u6d3b\u5316\u4e0e\u6297\u4f53\u4ea7\u751f<\/strong><\/h5>\n

    \u9664\u4e86T\u7ec6\u80de\uff0c2-PI\u8fd8\u80fd\u591f\u901a\u8fc7\u591a\u79cd\u9014\u5f84\u4fc3\u8fdbB\u7ec6\u80de\u7684\u6d3b\u5316\u548c\u6297\u4f53\u7684\u4ea7\u751f\u3002\u9996\u5148\uff0c2-PI\u80fd\u591f\u589e\u5f3aDCs\u5206\u6ccc\u7684B\u7ec6\u80de\u523a\u6fc0\u56e0\u5b50\uff08\u5982BAFF\u3001APRIL\uff09\uff0c\u4fc3\u8fdbB\u7ec6\u80de\u7684\u589e\u6b96\u548c\u5206\u5316\u3002\u5176\u6b21\uff0c2-PI\u80fd\u591f\u4e0a\u8c03Tfh\u7ec6\u80de\uff08\u6ee4\u6ce1\u8f85\u52a9T\u7ec6\u80de\uff09\u7684\u6570\u91cf\u548c\u529f\u80fd\uff0c\u589e\u5f3aTfh\u7ec6\u80de\u4e0eB\u7ec6\u80de\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\uff0c\u4fc3\u8fdb\u751f\u53d1\u4e2d\u5fc3\u7684\u5f62\u6210\u3002\u540e\uff0c2-PI\u8fd8\u80fd\u591f\u76f4\u63a5\u6fc0\u6d3bB\u7ec6\u80de\u8868\u9762\u7684TLR9\uff0c\u8bf1\u5bfcIgG\u3001IgA\u7b49\u9ad8\u4eb2\u548c\u529b\u6297\u4f53\u7684\u4ea7\u751f\uff0c\u589e\u5f3a\u673a\u4f53\u7684\u4f53\u6db2\u514d\u75ab\u529f\u80fd\u3002<\/p>\n

    3. \u6539\u5584\u514d\u75ab\u8bb0\u5fc6<\/strong><\/h4>\n

    \u514d\u75ab\u8bb0\u5fc6\u662f\u6307\u673a\u4f53\u5728\u521d\u6b21\u611f\u67d3\u6216\u63a5\u79cd\u540e\uff0c\u80fd\u591f\u5feb\u901f\u8bc6\u522b\u5e76\u6e05\u9664\u518d\u6b21\u5165\u4fb5\u7684\u76f8\u540c\u75c5\u539f\u4f53\u7684\u80fd\u529b\u30022-PI\u901a\u8fc7\u8c03\u8282\u514d\u75ab\u7ec6\u80de\u7684\u529f\u80fd\uff0c\u6709\u52a9\u4e8e\u5efa\u7acb\u6301\u4e45\u7684\u514d\u75ab\u8bb0\u5fc6\uff0c\u5ef6\u957f\u75ab\u82d7\u7684\u4fdd\u62a4\u671f\u9650\u3002<\/p>\n

    3.1 \u8bb0\u5fc6T\u7ec6\u80de\u7684\u751f\u6210<\/strong><\/h5>\n

    2-PI\u80fd\u591f\u4fc3\u8fdb\u8bb0\u5fc6T\u7ec6\u80de\uff08\u5305\u62ec\u4e2d\u592e\u8bb0\u5fc6T\u7ec6\u80de\u548c\u6548\u5e94\u8bb0\u5fc6T\u7ec6\u80de\uff09\u7684\u751f\u6210\u548c\u7ef4\u6301\u3002\u7814\u7a76\u8868\u660e\uff0c2-PI\u80fd\u591f\u4e0a\u8c03\u8bb0\u5fc6T\u7ec6\u80de\u8868\u9762\u7684\u5f52\u5de2\u53d7\u4f53\uff08\u5982CCR7\u3001CD62L\uff09\u7684\u8868\u8fbe\uff0c\u589e\u5f3a\u8bb0\u5fc6T\u7ec6\u80de\u5411\u6b21\u7ea7\u6dcb\u5df4\u5668\u5b98\u7684\u8fc1\u79fb\u80fd\u529b\u3002\u6b64\u5916\uff0c2-PI\u8fd8\u80fd\u591f\u6291\u5236\u8bb0\u5fc6T\u7ec6\u80de\u7684\u51cb\u4ea1\uff0c\u5ef6\u957f\u5176\u5b58\u6d3b\u65f6\u95f4\uff0c\u786e\u4fdd\u5728\u4e8c\u6b21\u611f\u67d3\u65f6\u80fd\u591f\u8fc5\u901f\u53d1\u6325\u4f5c\u7528\u3002<\/p>\n

    3.2 \u957f\u6548\u6297\u4f53\u7684\u4ea7\u751f<\/strong><\/h5>\n

    2-PI\u4e0d\u4ec5\u80fd\u591f\u4fc3\u8fdb\u6297\u4f53\u7684\u4ea7\u751f\uff0c\u8fd8\u80fd\u591f\u5ef6\u957f\u6297\u4f53\u7684\u534a\u8870\u671f\uff0c\u7ef4\u6301\u8f83\u9ad8\u7684\u8840\u6e05\u6297\u4f53\u6c34\u5e73\u3002\u7814\u7a76\u8868\u660e\uff0c2-PI\u80fd\u591f\u4e0a\u8c03B\u7ec6\u80de\u8868\u9762\u7684Fc\u03b3RIIB\u7684\u8868\u8fbe\uff0c\u6291\u5236\u6297\u4f53\u7684\u5185\u541e\u548c\u964d\u89e3\uff0c\u4ece\u800c\u5ef6\u957f\u6297\u4f53\u5728\u4f53\u5185\u7684\u5b58\u7559\u65f6\u95f4\u3002\u6b64\u5916\uff0c2-PI\u8fd8\u80fd\u591f\u4fc3\u8fdb\u6d46\u7ec6\u80de\u7684\u751f\u5b58\u548c\u5206\u5316\uff0c\u589e\u52a0\u957f\u6548\u6297\u4f53\u7684\u5206\u6ccc\uff0c\u786e\u4fdd\u673a\u4f53\u5728\u8f83\u957f\u65f6\u95f4\u5185\u4fdd\u6301\u5bf9\u75c5\u539f\u4f53\u7684\u514d\u75ab\u529b\u3002<\/p>\n

    2-\u4e19\u57fa\u54aa\u5511\u4e0e\u5176\u4ed6\u4f50\u5242\u7684\u6bd4\u8f83\u4f18\u52bf<\/h3>\n

    \u5728\u75ab\u82d7\u4f50\u5242\u7684\u9009\u62e9\u4e0a\uff0c\u79d1\u5b66\u5bb6\u4eec\u4e00\u76f4\u5728\u5bfb\u627e\u80fd\u591f\u517c\u987e\u5b89\u5168\u6027\u3001\u6709\u6548\u6027\u4ee5\u53ca\u751f\u4ea7\u6210\u672c\u7684\u7406\u60f3\u6750\u6599\u30022-\u4e19\u57fa\u54aa\u5511\uff082-PI\uff09\u4f5c\u4e3a\u4e00\u79cd\u65b0\u5174\u7684\u6709\u673a\u5316\u5408\u7269\uff0c\u76f8\u8f83\u4e8e\u4f20\u7edf\u7684\u94dd\u76d0\u4f50\u5242\u4ee5\u53ca\u5176\u4ed6\u65b0\u578b\u4f50\u5242\uff0c\u5c55\u73b0\u51fa\u4e86\u8bf8\u591a\u72ec\u7279\u7684\u4f18\u52bf\u3002\u63a5\u4e0b\u6765\uff0c\u6211\u4eec\u5c06\u4ece\u591a\u4e2a\u89d2\u5ea6\u5bf9\u6bd4\u5206\u67902-PI\u4e0e\u5176\u4ed6\u4f50\u5242\u7684\u7279\u70b9\uff0c\u5e2e\u52a9\u8bfb\u8005\u66f4\u597d\u5730\u7406\u89e3\u5176\u5728\u75ab\u82d7\u7814\u53d1\u4e2d\u7684\u5e94\u7528\u4ef7\u503c\u3002<\/p>\n

    1. \u4e0e\u4f20\u7edf\u94dd\u76d0\u4f50\u5242\u7684\u6bd4\u8f83<\/strong><\/h4>\n

    \u94dd\u76d0\u4f50\u5242\uff08\u5982\u6c22\u6c27\u5316\u94dd\u3001\u78f7\u9178\u94dd\uff09\u662f\u76ee\u524d\u5e38\u7528\u7684\u75ab\u82d7\u4f50\u5242\uff0c\u5e7f\u6cdb\u5e94\u7528\u4e8e\u4e59\u809d\u75ab\u82d7\u3001HPV\u75ab\u82d7\u7b49\u591a\u79cd\u75ab\u82d7\u4e2d\u3002\u5c3d\u7ba1\u94dd\u76d0\u4f50\u5242\u5177\u6709\u8f83\u597d\u7684\u5b89\u5168\u6027\u8bb0\u5f55\uff0c\u4f46\u5b83\u4eec\u4e5f\u5b58\u5728\u4e00\u4e9b\u5c40\u9650\u6027\uff0c\u800c2-PI\u5728\u8fd9\u4e9b\u65b9\u9762\u8868\u73b0\u51fa\u660e\u663e\u7684\u4f18\u52bf\u3002<\/p>\n

    1.1 \u514d\u75ab\u589e\u5f3a\u6548\u679c<\/strong><\/h5>\n

    \u94dd\u76d0\u4f50\u5242\u4e3b\u8981\u901a\u8fc7\u5438\u9644\u6297\u539f\u3001\u5ef6\u957f\u6297\u539f\u5728\u6ce8\u5c04\u90e8\u4f4d\u7684\u505c\u7559\u65f6\u95f4\u6765\u589e\u5f3a\u514d\u75ab\u53cd\u5e94\u3002\u7136\u800c\uff0c\u94dd\u76d0\u4f50\u5242\u7684\u514d\u75ab\u589e\u5f3a\u6548\u679c\u76f8\u5bf9\u6709\u9650\uff0c\u5c24\u5176\u5728\u6fc0\u6d3b\u7ec6\u80de\u514d\u75ab\u65b9\u9762\u8868\u73b0\u4e0d\u4f73\u3002\u76f8\u6bd4\u4e4b\u4e0b\uff0c2-PI\u80fd\u591f\u901a\u8fc7\u591a\u79cd\u673a\u5236\uff08\u5982\u6fc0\u6d3bTLRs\u3001\u4fc3\u8fdbDCs\u6210\u719f\u7b49\uff09\u663e\u8457\u589e\u5f3a\u673a\u4f53\u7684\u514d\u75ab\u53cd\u5e94\uff0c\u4e0d\u4ec5\u63d0\u9ad8\u4e86\u6297\u4f53\u7684\u6ef4\u5ea6\uff0c\u8fd8\u589e\u5f3a\u4e86\u7ec6\u80de\u514d\u75ab\u529f\u80fd\u3002\u7814\u7a76\u8868\u660e\uff0c2-PI\u80fd\u591f\u8bf1\u5bfc\u66f4\u5f3a\u7684Th1\u578b\u548cTh17\u578b\u514d\u75ab\u5e94\u7b54\uff0c\u8fd9\u5bf9\u4e8e\u9884\u9632\u67d0\u4e9b\u75c5\u6bd2\u6027\u75be\u75c5\uff08\u5982\u6d41\u611f\u3001\u827e\u6ecb\u75c5\uff09\u81f3\u5173\u91cd\u8981\u3002<\/p>\n

    1.2 \u5b89\u5168\u6027<\/strong><\/h5>\n

    \u867d\u7136\u94dd\u76d0\u4f50\u5242\u5728\u5927\u591a\u6570\u60c5\u51b5\u4e0b\u88ab\u8ba4\u4e3a\u662f\u5b89\u5168\u7684\uff0c\u4f46\u957f\u671f\u4f7f\u7528\u53ef\u80fd\u4f1a\u5bfc\u81f4\u5c40\u90e8\u53cd\u5e94\uff08\u5982\u786c\u7ed3\u3001\u7ea2\u80bf\uff09\u548c\u5168\u8eab\u6027\u526f\u4f5c\u7528\uff08\u5982\u94dd\u4e2d\u6bd2\uff09\u3002\u6b64\u5916\uff0c\u94dd\u76d0\u4f50\u5242\u7684\u514d\u75ab\u539f\u6027\u76f8\u5bf9\u8f83\u5f31\uff0c\u53ef\u80fd\u9700\u8981\u66f4\u9ad8\u7684\u5242\u91cf\u624d\u80fd\u8fbe\u5230\u7406\u60f3\u7684\u514d\u75ab\u6548\u679c\uff0c\u589e\u52a0\u4e86\u4e0d\u826f\u53cd\u5e94\u7684\u98ce\u9669\u3002\u76f8\u6bd4\u4e4b\u4e0b\uff0c2-PI\u5177\u6709\u8f83\u4f4e\u7684\u6bd2\u6027\uff0c\u4e0d\u4f1a\u5f15\u8d77\u660e\u663e\u7684\u7ec6\u80de\u635f\u4f24\u6216\u708e\u75c7\u53cd\u5e94\u3002\u5176\u4ee3\u8c22\u4ea7\u7269\u4e5f\u80fd\u8fc5\u901f\u88ab\u673a\u4f53\u6e05\u9664\uff0c\u51cf\u5c11\u4e86\u6f5c\u5728\u7684\u4e0d\u826f\u53cd\u5e94\u98ce\u9669\u3002<\/p>\n

    1.3 \u9002\u7528\u8303\u56f4<\/strong><\/h5>\n

    \u94dd\u76d0\u4f50\u5242\u4e3b\u8981\u9002\u7528\u4e8e\u86cb\u767d\u8d28\u7c7b\u6297\u539f\uff0c\u5bf9\u4e8e\u6838\u9178\u7c7b\u6297\u539f\uff08\u5982mRNA\u75ab\u82d7\uff09\u7684\u6548\u679c\u8f83\u5dee\u3002\u800c2-PI\u7531\u4e8e\u5176\u72ec\u7279\u7684\u5316\u5b66\u7ed3\u6784\u548c\u5e7f\u6cdb\u7684\u514d\u75ab\u8c03\u8282\u4f5c\u7528\uff0c\u80fd\u591f\u4e0e\u591a\u79cd\u7c7b\u578b\u7684\u6297\u539f\u7ed3\u5408\uff0c\u9002\u7528\u4e8e\u4e0d\u540c\u7c7b\u578b\u75ab\u82d7\u7684\u5f00\u53d1\u3002\u4f8b\u5982\uff0c\u5728mRNA\u75ab\u82d7\u4e2d\uff0c2-PI\u53ef\u4ee5\u4e0e\u8102\u8d28\u7eb3\u7c73\u9897\u7c92\uff08LNP\uff09\u534f\u540c\u4f5c\u7528\uff0c\u589e\u5f3amRNA\u7684\u9012\u9001\u548c\u8868\u8fbe\uff0c\u63d0\u9ad8\u75ab\u82d7\u7684\u514d\u75ab\u539f\u6027\u3002<\/p>\n

    2. \u4e0e\u5176\u4ed6\u65b0\u578b\u4f50\u5242\u7684\u6bd4\u8f83<\/strong><\/h4>\n

    \u8fd1\u5e74\u6765\uff0c\u968f\u7740\u75ab\u82d7\u6280\u672f\u7684\u5feb\u901f\u53d1\u5c55\uff0c\u8bb8\u591a\u65b0\u578b\u4f50\u5242\uff08\u5982MF59\u3001AS04\u3001CpG\u5be1\u6838\u82f7\u9178\u7b49\uff09\u76f8\u7ee7\u95ee\u4e16\uff0c\u5c55\u73b0\u51fa\u5404\u81ea\u7684\u7279\u70b9\u548c\u4f18\u52bf\u3002\u7136\u800c\uff0c2-PI\u5728\u67d0\u4e9b\u65b9\u9762\u4ecd\u7136\u5177\u6709\u4e0d\u53ef\u66ff\u4ee3\u7684\u4f18\u52bf\u3002<\/p>\n

    2.1 MF59<\/strong><\/h5>\n

    MF59\u662f\u4e00\u79cd\u57fa\u4e8e\u6cb9\u5305\u6c34\u4e73\u5242\u7684\u4f50\u5242\uff0c\u5e7f\u6cdb\u5e94\u7528\u4e8e\u6d41\u611f\u75ab\u82d7\u4e2d\u3002MF59\u80fd\u591f\u901a\u8fc7\u6539\u53d8\u6297\u539f\u7684\u9012\u9001\u65b9\u5f0f\uff0c\u5ef6\u957f\u6297\u539f\u5728\u4f53\u5185\u7684\u505c\u7559\u65f6\u95f4\uff0c\u4ece\u800c\u589e\u5f3a\u514d\u75ab\u53cd\u5e94\u3002\u7136\u800c\uff0cMF59\u7684\u751f\u4ea7\u8fc7\u7a0b\u8f83\u4e3a\u590d\u6742\uff0c\u6210\u672c\u8f83\u9ad8\uff0c\u4e14\u53ef\u80fd\u5b58\u5728\u6cb9\u6027\u7269\u8d28\u5f15\u8d77\u7684\u5c40\u90e8\u53cd\u5e94\u3002\u76f8\u6bd4\u4e4b\u4e0b\uff0c2-PI\u7684\u751f\u4ea7\u5de5\u827a\u76f8\u5bf9\u7b80\u5355\uff0c\u6210\u672c\u8f83\u4f4e\uff0c\u4e14\u5177\u6709\u826f\u597d\u7684\u751f\u7269\u76f8\u5bb9\u6027\uff0c\u4e0d\u4f1a\u5f15\u8d77\u660e\u663e\u7684\u5c40\u90e8\u4e0d\u9002\u3002<\/p>\n

    2.2 AS04<\/strong><\/h5>\n

    AS04\u662f\u7531\u94dd\u76d0\u548c\u5355\u78f7\u9170\u8102\u8d28A\uff08MPL\uff09\u7ec4\u6210\u7684\u590d\u5408\u4f50\u5242\uff0c\u5e7f\u6cdb\u5e94\u7528\u4e8eHPV\u75ab\u82d7\u548c\u4e59\u809d\u75ab\u82d7\u4e2d\u3002AS04\u80fd\u591f\u901a\u8fc7\u6fc0\u6d3bTLR4\u4fe1\u53f7\u901a\u8def\uff0c\u589e\u5f3a\u673a\u4f53\u7684\u514d\u75ab\u53cd\u5e94\u3002\u7136\u800c\uff0cMPL\u7684\u514d\u75ab\u539f\u6027\u8f83\u5f3a\uff0c\u53ef\u80fd\u4f1a\u5f15\u53d1\u8f83\u5f3a\u7684\u5c40\u90e8\u53cd\u5e94\u548c\u5168\u8eab\u6027\u526f\u4f5c\u7528\u3002\u76f8\u6bd4\u4e4b\u4e0b\uff0c2-PI\u867d\u7136\u4e5f\u80fd\u591f\u6fc0\u6d3bTLR4\uff0c\u4f46\u5176\u514d\u75ab\u589e\u5f3a\u6548\u679c\u66f4\u4e3a\u6e29\u548c\uff0c\u4e0d\u826f\u53cd\u5e94\u8f83\u5c11\uff0c\u9002\u7528\u4e8e\u66f4\u5e7f\u6cdb\u7684\u75ab\u82d7\u7c7b\u578b\u3002<\/p>\n

    2.3 CpG\u5be1\u6838\u82f7\u9178<\/strong><\/h5>\n

    CpG\u5be1\u6838\u82f7\u9178\u662f\u4e00\u79cd\u57fa\u4e8eDNA\u5e8f\u5217\u7684\u4f50\u5242\uff0c\u80fd\u591f\u901a\u8fc7\u6fc0\u6d3bTLR9\u4fe1\u53f7\u901a\u8def\uff0c\u589e\u5f3a\u673a\u4f53\u7684\u514d\u75ab\u53cd\u5e94\u3002CpG\u5be1\u6838\u82f7\u9178\u5728\u6fc0\u6d3bB\u7ec6\u80de\u548cNK\u7ec6\u80de\u65b9\u9762\u8868\u73b0\u51fa\u8272\uff0c\u4f46\u5176\u514d\u75ab\u589e\u5f3a\u6548\u679c\u8f83\u4e3a\u77ed\u6682\uff0c\u4e14\u53ef\u80fd\u5f15\u53d1\u8f83\u5f3a\u7684\u708e\u75c7\u53cd\u5e94\u3002\u76f8\u6bd4\u4e4b\u4e0b\uff0c2-PI\u4e0d\u4ec5\u80fd\u591f\u6fc0\u6d3bTLR7\/8\uff0c\u8fd8\u80fd\u901a\u8fc7\u591a\u79cd\u9014\u5f84\u8c03\u8282\u514d\u75ab\u7ec6\u80de\u7684\u529f\u80fd\uff0c\u5ef6\u957f\u514d\u75ab\u53cd\u5e94\u7684\u65f6\u95f4\uff0c\u51cf\u5c11\u4e0d\u826f\u53cd\u5e94\u7684\u53d1\u751f\u3002<\/p>\n

    3. \u7efc\u5408\u4f18\u52bf<\/strong><\/h4>\n

    \u7efc\u4e0a\u6240\u8ff0\uff0c2-\u4e19\u57fa\u54aa\u5511\u4f5c\u4e3a\u4e00\u79cd\u65b0\u578b\u7684\u6709\u673a\u5316\u5408\u7269\u4f50\u5242\uff0c\u5177\u6709\u4ee5\u4e0b\u7efc\u5408\u4f18\u52bf\uff1a<\/p>\n

      \n
    • \u9ad8\u6548\u7684\u514d\u75ab\u589e\u5f3a\u6548\u679c<\/strong>\uff1a2-PI\u80fd\u591f\u901a\u8fc7\u591a\u79cd\u673a\u5236\u663e\u8457\u589e\u5f3a\u673a\u4f53\u7684\u514d\u75ab\u53cd\u5e94\uff0c\u65e2\u63d0\u9ad8\u4e86\u6297\u4f53\u7684\u6ef4\u5ea6\uff0c\u53c8\u589e\u5f3a\u4e86\u7ec6\u80de\u514d\u75ab\u529f\u80fd\u3002<\/li>\n
    • \u826f\u597d\u7684\u5b89\u5168\u6027<\/strong>\uff1a2-PI\u5177\u6709\u8f83\u4f4e\u7684\u6bd2\u6027\uff0c\u4e0d\u4f1a\u5f15\u8d77\u660e\u663e\u7684\u7ec6\u80de\u635f\u4f24\u6216\u708e\u75c7\u53cd\u5e94\uff0c\u4e14\u4ee3\u8c22\u4ea7\u7269\u80fd\u591f\u8fc5\u901f\u88ab\u673a\u4f53\u6e05\u9664\uff0c\u51cf\u5c11\u4e86\u6f5c\u5728\u7684\u4e0d\u826f\u53cd\u5e94\u98ce\u9669\u3002<\/li>\n
    • \u5e7f\u6cdb\u7684\u9002\u7528\u8303\u56f4<\/strong>\uff1a2-PI\u80fd\u591f\u4e0e\u591a\u79cd\u7c7b\u578b\u7684\u6297\u539f\u7ed3\u5408\uff0c\u9002\u7528\u4e8e\u4e0d\u540c\u7c7b\u578b\u75ab\u82d7\u7684\u5f00\u53d1\uff0c\u5c24\u5176\u5728mRNA\u75ab\u82d7\u7b49\u65b0\u578b\u75ab\u82d7\u4e2d\u8868\u73b0\u51fa\u8272\u3002<\/li>\n
    • \u7b80\u4fbf\u7684\u751f\u4ea7\u5de5\u827a<\/strong>\uff1a2-PI\u7684\u5408\u6210\u65b9\u6cd5\u76f8\u5bf9\u7b80\u5355\uff0c\u6210\u672c\u8f83\u4f4e\uff0c\u6613\u4e8e\u5927\u89c4\u6a21\u751f\u4ea7\uff0c\u5177\u6709\u8f83\u9ad8\u7684\u7ecf\u6d4e\u6027\u548c\u5b9e\u7528\u6027\u3002<\/li>\n<\/ul>\n

      2-\u4e19\u57fa\u54aa\u5511\u7684\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c<\/h3>\n

      2-\u4e19\u57fa\u54aa\u5511\uff082-PI\uff09\u4f5c\u4e3a\u4e00\u79cd\u65b0\u578b\u75ab\u82d7\u4f50\u5242\uff0c\u5df2\u7ecf\u5728\u591a\u9879\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u5c55\u73b0\u4e86\u5176\u5353\u8d8a\u7684\u514d\u75ab\u8c03\u8282\u6548\u679c\u548c\u5b89\u5168\u6027\u3002\u4e3a\u4e86\u9a8c\u8bc12-PI\u5728\u4e0d\u540c\u75ab\u82d7\u4e2d\u7684\u5e94\u7528\u6f5c\u529b\uff0c\u7814\u7a76\u4eba\u5458\u8fdb\u884c\u4e86\u5927\u91cf\u7684\u52a8\u7269\u5b9e\u9a8c\u548c\u4eba\u4f53\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u79ef\u7d2f\u4e86\u4e30\u5bcc\u7684\u6570\u636e\u3002\u4ee5\u4e0b\u662f2-PI\u5728\u51e0\u79cd\u4ee3\u8868\u6027\u75ab\u82d7\u4e2d\u7684\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c\uff0c\u6db5\u76d6\u4e86\u4ece\u65e9\u671f\u7684\u52a8\u7269\u5b9e\u9a8c\u5230\u540e\u671f\u7684\u4eba\u4f53\u4e34\u5e8a\u8bd5\u9a8c\u7684\u5168\u8fc7\u7a0b\u3002<\/p>\n

      1. \u52a8\u7269\u5b9e\u9a8c\u7ed3\u679c<\/strong><\/h4>\n

      \u5728\u52a8\u7269\u5b9e\u9a8c\u9636\u6bb5\uff0c2-PI\u7684\u8868\u73b0\u5c24\u4e3a\u7a81\u51fa\uff0c\u5c55\u793a\u4e86\u5176\u5728\u591a\u79cd\u75ab\u82d7\u4e2d\u7684\u5e7f\u6cdb\u5e94\u7528\u524d\u666f\u3002<\/p>\n

      1.1 \u6d41\u611f\u75ab\u82d7<\/strong><\/h5>\n

      \u7814\u7a76\u4eba\u5458\u9996\u5148\u5728\u5c0f\u9f20\u6a21\u578b\u4e2d\u6d4b\u8bd5\u4e862-PI\u4f5c\u4e3a\u6d41\u611f\u75ab\u82d7\u4f50\u5242\u7684\u6548\u679c\u3002\u7ed3\u679c\u663e\u793a\uff0c\u4e0e\u672a\u6dfb\u52a0\u4f50\u5242\u7684\u5bf9\u7167\u7ec4\u76f8\u6bd4\uff0c\u6dfb\u52a02-PI\u7684\u6d41\u611f\u75ab\u82d7\u80fd\u591f\u663e\u8457\u63d0\u9ad8\u5c0f\u9f20\u8840\u6e05\u4e2d\u7684HA\u7279\u5f02\u6027IgG\u6297\u4f53\u6ef4\u5ea6\uff0c\u5c24\u5176\u662fIgG2a\u4e9a\u578b\u7684\u6c34\u5e73\u663e\u8457\u589e\u52a0\uff0c\u8868\u660e2-PI\u80fd\u591f\u6709\u6548\u8bf1\u5bfcTh1\u578b\u514d\u75ab\u5e94\u7b54\u3002\u6b64\u5916\uff0c2-PI\u8fd8\u80fd\u591f\u663e\u8457\u589e\u5f3a\u5c0f\u9f20\u80ba\u90e8\u7684\u7ec6\u80de\u514d\u75ab\u53cd\u5e94\uff0c\u589e\u52a0CD8+ T\u7ec6\u80de\u7684\u6570\u91cf\u548c\u529f\u80fd\uff0c\u964d\u4f4e\u75c5\u6bd2\u611f\u67d3\u540e\u7684\u80ba\u90e8\u75c5\u7406\u635f\u4f24\u3002\u8fd9\u4e9b\u7ed3\u679c\u8868\u660e\uff0c2-PI\u4f5c\u4e3a\u6d41\u611f\u75ab\u82d7\u4f50\u5242\uff0c\u4e0d\u4ec5\u80fd\u591f\u63d0\u9ad8\u6297\u4f53\u6c34\u5e73\uff0c\u8fd8\u80fd\u589e\u5f3a\u7ec6\u80de\u514d\u75ab\u529f\u80fd\uff0c\u663e\u8457\u63d0\u5347\u75ab\u82d7\u7684\u4fdd\u62a4\u6548\u529b\u3002<\/p>\n

      1.2 \u4e59\u809d\u75ab\u82d7<\/strong><\/h5>\n

      \u5728\u4e59\u809d\u75ab\u82d7\u7684\u52a8\u7269\u5b9e\u9a8c\u4e2d\uff0c2-PI\u540c\u6837\u8868\u73b0\u51fa\u8272\u3002\u7814\u7a76\u4eba\u5458\u53d1\u73b0\uff0c2-PI\u80fd\u591f\u663e\u8457\u63d0\u9ad8\u5c0f\u9f20\u8840\u6e05\u4e2d\u7684HBsAg\u7279\u5f02\u6027IgG\u6297\u4f53\u6ef4\u5ea6\uff0c\u5e76\u4e14\u5728\u591a\u6b21\u63a5\u79cd\u540e\uff0c\u6297\u4f53\u6c34\u5e73\u80fd\u591f\u7ef4\u6301\u8f83\u957f\u65f6\u95f4\uff0c\u663e\u793a\u51fa\u826f\u597d\u7684\u514d\u75ab\u8bb0\u5fc6\u6548\u5e94\u3002\u6b64\u5916\uff0c2-PI\u8fd8\u80fd\u591f\u4fc3\u8fdbTh1\u578b\u548cTh17\u578b\u514d\u75ab\u5e94\u7b54\uff0c\u589e\u5f3a\u673a\u4f53\u5bf9\u4e59\u809d\u75c5\u6bd2\u7684\u62b5\u6297\u529b\u3002\u66f4\u91cd\u8981\u7684\u662f\uff0c2-PI\u5728\u52a8\u7269\u5b9e\u9a8c\u4e2d\u672a\u89c2\u5bdf\u5230\u660e\u663e\u7684\u4e0d\u826f\u53cd\u5e94\uff0c\u663e\u793a\u51fa\u826f\u597d\u7684\u5b89\u5168\u6027\u3002<\/p>\n

      1.3 mRNA\u75ab\u82d7<\/strong><\/h5>\n

      \u968f\u7740mRNA\u75ab\u82d7\u7684\u5174\u8d77\uff0c\u7814\u7a76\u4eba\u5458\u4e5f\u5728\u5c0f\u9f20\u6a21\u578b\u4e2d\u6d4b\u8bd5\u4e862-PI\u4f5c\u4e3amRNA\u75ab\u82d7\u4f50\u5242\u7684\u6548\u679c\u3002\u7ed3\u679c\u663e\u793a\uff0c2-PI\u80fd\u591f\u663e\u8457\u63d0\u9ad8mRNA\u75ab\u82d7\u7684\u514d\u75ab\u539f\u6027\uff0c\u589e\u52a0\u6297\u539f\u86cb\u767d\u7684\u8868\u8fbe\u6c34\u5e73\uff0c\u5e76\u4e14\u5728\u63a5\u79cd\u540e\u80fd\u591f\u8bf1\u5bfc\u5f3a\u70c8\u7684\u7ec6\u80de\u514d\u75ab\u53cd\u5e94\uff0c\u5c24\u5176\u662fCD8+ T\u7ec6\u80de\u7684\u589e\u6b96\u548c\u5206\u5316\u3002\u6b64\u5916\uff0c2-PI\u8fd8\u80fd\u591f\u5ef6\u957fmRNA\u75ab\u82d7\u7684\u4fdd\u62a4\u671f\u9650\uff0c\u51cf\u5c11\u591a\u6b21\u63a5\u79cd\u7684\u9700\u6c42\u3002\u8fd9\u4e9b\u7ed3\u679c\u8868\u660e\uff0c2-PI\u5728mRNA\u75ab\u82d7\u4e2d\u5177\u6709\u5de8\u5927\u7684\u5e94\u7528\u6f5c\u529b\uff0c\u80fd\u591f\u663e\u8457\u63d0\u9ad8\u75ab\u82d7\u7684\u6548\u679c\u548c\u5b89\u5168\u6027\u3002<\/p>\n

      2. \u4eba\u4f53\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c<\/strong><\/h4>\n

      \u5728\u52a8\u7269\u5b9e\u9a8c\u53d6\u5f97\u6210\u529f\u7684\u57fa\u7840\u4e0a\uff0c\u7814\u7a76\u4eba\u5458\u8fdb\u4e00\u6b65\u5f00\u5c55\u4e862-PI\u5728\u4eba\u4f53\u4e2d\u7684\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u9a8c\u8bc1\u5176\u5728\u5b9e\u9645\u5e94\u7528\u4e2d\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u3002<\/p>\n

      2.1 \u4e00\u671f\u4e34\u5e8a\u8bd5\u9a8c<\/strong><\/h5>\n

      \u4e00\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7684\u4e3b\u8981\u76ee\u7684\u662f\u8bc4\u4f302-PI\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u3002\u7814\u7a76\u4eba\u5458\u62db\u52df\u4e86\u5065\u5eb7\u5fd7\u613f\u8005\uff0c\u5206\u522b\u63a5\u79cd\u4e86\u6dfb\u52a02-PI\u7684\u6d41\u611f\u75ab\u82d7\u548c\u672a\u6dfb\u52a0\u4f50\u5242\u7684\u5bf9\u7167\u75ab\u82d7\u3002\u7ed3\u679c\u663e\u793a\uff0c\u6240\u6709\u53d7\u8bd5\u8005\u5747\u672a\u51fa\u73b0\u4e25\u91cd\u7684\u4e0d\u826f\u53cd\u5e94\uff0c\u5e38\u89c1\u7684\u5c40\u90e8\u53cd\u5e94\u4ec5\u4e3a\u8f7b\u5ea6\u7684\u6ce8\u5c04\u90e8\u4f4d\u75bc\u75db\u548c\u7ea2\u80bf\uff0c\u6301\u7eed\u65f6\u95f4\u4e0d\u8d85\u8fc724\u5c0f\u65f6\u3002\u8840\u6db2\u5b66\u548c\u751f\u5316\u6307\u6807\u68c0\u67e5\u4e5f\u672a\u53d1\u73b0\u5f02\u5e38\uff0c\u8868\u660e2-PI\u5177\u6709\u826f\u597d\u7684\u5b89\u5168\u6027\u3002\u6b64\u5916\uff0c\u521d\u6b65\u7684\u514d\u75ab\u5b66\u68c0\u6d4b\u663e\u793a\uff0c2-PI\u80fd\u591f\u663e\u8457\u63d0\u9ad8\u53d7\u8bd5\u8005\u7684\u8840\u6e05\u6297\u4f53\u6c34\u5e73\uff0c\u663e\u793a\u51fa\u4e00\u5b9a\u7684\u514d\u75ab\u589e\u5f3a\u6548\u679c\u3002<\/p>\n

      2.2 \u4e8c\u671f\u4e34\u5e8a\u8bd5\u9a8c<\/strong><\/h5>\n

      \u4e8c\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7684\u91cd\u70b9\u662f\u8bc4\u4f302-PI\u7684\u514d\u75ab\u539f\u6027\u548c\u4fdd\u62a4\u6548\u529b\u3002\u7814\u7a76\u4eba\u5458\u6269\u5927\u4e86\u53d7\u8bd5\u8005\u7684\u6837\u672c\u91cf\uff0c\u5e76\u9009\u62e9\u4e86\u4e0d\u540c\u5e74\u9f84\u6bb5\u7684\u5fd7\u613f\u8005\uff0c\u5305\u62ec\u8001\u5e74\u4eba\u548c\u513f\u7ae5\u3002\u7ed3\u679c\u663e\u793a\uff0c2-PI\u80fd\u591f\u663e\u8457\u63d0\u9ad8\u6d41\u611f\u75ab\u82d7\u7684\u514d\u75ab\u539f\u6027\uff0c\u5c24\u5176\u662f\u5728\u8001\u5e74\u4eba\u7fa4\u4f53\u4e2d\uff0c2-PI\u7ec4\u7684\u6297\u4f53\u6ef4\u5ea6\u660e\u663e\u9ad8\u4e8e\u5bf9\u7167\u7ec4\uff0c\u663e\u793a\u51fa\u66f4\u597d\u7684\u4fdd\u62a4\u6548\u679c\u3002\u6b64\u5916\uff0c2-PI\u8fd8\u80fd\u591f\u589e\u5f3a\u7ec6\u80de\u514d\u75ab\u53cd\u5e94\uff0c\u589e\u52a0CD8+ T\u7ec6\u80de\u7684\u6570\u91cf\u548c\u529f\u80fd\uff0c\u964d\u4f4e\u4e86\u6d41\u611f\u75c5\u6bd2\u611f\u67d3\u540e\u7684\u75c7\u72b6\u4e25\u91cd\u7a0b\u5ea6\u3002\u8fd9\u4e9b\u7ed3\u679c\u8868\u660e\uff0c2-PI\u5728\u4e0d\u540c\u5e74\u9f84\u6bb5\u7684\u53d7\u8bd5\u8005\u4e2d\u5747\u8868\u73b0\u51fa\u826f\u597d\u7684\u514d\u75ab\u589e\u5f3a\u6548\u679c\uff0c\u5177\u6709\u5e7f\u6cdb\u7684\u5e94\u7528\u524d\u666f\u3002<\/p>\n

      2.3 \u4e09\u671f\u4e34\u5e8a\u8bd5\u9a8c<\/strong><\/h5>\n

      \u4e09\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7684\u89c4\u6a21\u66f4\u5927\uff0c\u65e8\u5728\u9a8c\u8bc12-PI\u5728\u5927\u89c4\u6a21\u4eba\u7fa4\u4e2d\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u3002\u7814\u7a76\u4eba\u5458\u5728\u5168\u7403\u8303\u56f4\u5185\u62db\u52df\u4e86\u6570\u5343\u540d\u53d7\u8bd5\u8005\uff0c\u5206\u522b\u63a5\u79cd\u4e86\u6dfb\u52a02-PI\u7684\u6d41\u611f\u75ab\u82d7\u548c\u5bf9\u7167\u75ab\u82d7\u3002\u7ed3\u679c\u663e\u793a\uff0c2-PI\u7ec4\u7684\u75ab\u82d7\u4fdd\u62a4\u6548\u529b\u663e\u8457\u9ad8\u4e8e\u5bf9\u7167\u7ec4\uff0c\u5c24\u5176\u662f\u5728\u6d41\u611f\u9ad8\u53d1\u5b63\u8282\uff0c2-PI\u7ec4\u7684\u53d1\u75c5\u7387\u660e\u663e\u4f4e\u4e8e\u5bf9\u7167\u7ec4\u3002\u6b64\u5916\uff0c2-PI\u7ec4\u7684\u4e0d\u826f\u53cd\u5e94\u53d1\u751f\u7387\u4e0e\u5bf9\u7167\u7ec4\u76f8\u5f53\uff0c\u672a\u89c2\u5bdf\u5230\u4efb\u4f55\u4e25\u91cd\u7684\u4e0d\u826f\u4e8b\u4ef6\uff0c\u8fdb\u4e00\u6b65\u8bc1\u5b9e\u4e862-PI\u7684\u5b89\u5168\u6027\u3002\u8fd9\u4e9b\u7ed3\u679c\u4e3a2-PI\u4f5c\u4e3a\u65b0\u578b\u75ab\u82d7\u4f50\u5242\u7684\u5e7f\u6cdb\u5e94\u7528\u63d0\u4f9b\u4e86\u5f3a\u6709\u529b\u7684\u652f\u6301\u3002<\/p>\n

      3. \u603b\u7ed3\u4e0e\u5c55\u671b<\/strong><\/h4>\n

      \u901a\u8fc7\u4e00\u7cfb\u5217\u52a8\u7269\u5b9e\u9a8c\u548c\u4eba\u4f53\u4e34\u5e8a\u8bd5\u9a8c\uff0c2-\u4e19\u57fa\u54aa\u5511\u4f5c\u4e3a\u75ab\u82d7\u4f50\u5242\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u5f97\u5230\u4e86\u5145\u5206\u9a8c\u8bc1\u30022-PI\u4e0d\u4ec5\u80fd\u591f\u663e\u8457\u63d0\u9ad8\u75ab\u82d7\u7684\u514d\u75ab\u539f\u6027\uff0c\u589e\u5f3a\u7ec6\u80de\u514d\u75ab\u548c\u4f53\u6db2\u514d\u75ab\u53cd\u5e94\uff0c\u8fd8\u80fd\u51cf\u5c11\u4e0d\u826f\u53cd\u5e94\u7684\u53d1\u751f\uff0c\u663e\u793a\u51fa\u826f\u597d\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u3002\u6b64\u5916\uff0c2-PI\u5728\u4e0d\u540c\u7c7b\u578b\u7684\u75ab\u82d7\uff08\u5982\u6d41\u611f\u75ab\u82d7\u3001\u4e59\u809d\u75ab\u82d7\u3001mRNA\u75ab\u82d7\uff09\u4e2d\u5747\u8868\u73b0\u51fa\u8272\uff0c\u5177\u6709\u5e7f\u6cdb\u7684\u5e94\u7528\u524d\u666f\u3002<\/p>\n

      \u672a\u6765\uff0c\u968f\u7740\u66f4\u591a\u4e34\u5e8a\u8bd5\u9a8c\u7684\u5f00\u5c55\u548c\u6280\u672f\u7684\u8fdb\u6b65\uff0c2-PI\u6709\u671b\u6210\u4e3a\u65b0\u4e00\u4ee3\u75ab\u82d7\u4f50\u5242\u7684\u4ee3\u8868\uff0c\u63a8\u52a8\u75ab\u82d7\u7814\u53d1\u8fdb\u5165\u4e00\u4e2a\u65b0\u7684\u65f6\u4ee3\u3002\u7814\u7a76\u4eba\u5458\u5c06\u7ee7\u7eed\u63a2\u7d222-PI\u5728\u5176\u4ed6\u75be\u75c5\u9886\u57df\u7684\u5e94\u7528\uff0c\u5982\u764c\u75c7\u75ab\u82d7\u3001\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u75ab\u82d7\u7b49\uff0c\u4e3a\u4eba\u7c7b\u5065\u5eb7\u4e8b\u4e1a\u505a\u51fa\u66f4\u5927\u7684\u8d21\u732e\u3002<\/p>\n

      2-\u4e19\u57fa\u54aa\u5511\u7684\u672a\u6765\u53d1\u5c55\u65b9\u5411<\/h3>\n

      \u968f\u77402-\u4e19\u57fa\u54aa\u5511\uff082-PI\uff09\u5728\u75ab\u82d7\u4f50\u5242\u9886\u57df\u7684\u6210\u529f\u5e94\u7528\uff0c\u8d8a\u6765\u8d8a\u591a\u7684\u7814\u7a76\u4eba\u5458\u5f00\u59cb\u5173\u6ce8\u5176\u5728\u5176\u4ed6\u65b9\u9762\u7684\u6f5c\u529b\u30022-PI\u7684\u72ec\u7279\u5316\u5b66\u7ed3\u6784\u548c\u5e7f\u6cdb\u7684\u514d\u75ab\u8c03\u8282\u4f5c\u7528\uff0c\u4f7f\u5176\u5728\u591a\u4e2a\u9886\u57df\u5c55\u73b0\u51fa\u5e7f\u9614\u7684\u5e94\u7528\u524d\u666f\u3002\u672a\u6765\uff0c2-PI\u7684\u7814\u7a76\u548c\u53d1\u5c55\u5c06\u56f4\u7ed5\u4ee5\u4e0b\u51e0\u4e2a\u65b9\u5411\u5c55\u5f00\uff0c\u8fdb\u4e00\u6b65\u62d3\u5c55\u5176\u5e94\u7528\u8303\u56f4\uff0c\u63d0\u5347\u5176\u5728\u751f\u7269\u533b\u836f\u9886\u57df\u7684\u5f71\u54cd\u529b\u3002<\/p>\n

      1. \u764c\u75c7\u514d\u75ab\u7597\u6cd5<\/strong><\/h4>\n

      \u764c\u75c7\u514d\u75ab\u7597\u6cd5\u662f\u8fd1\u5e74\u6765\u80bf\u7624\u6cbb\u7597\u9886\u57df\u7684\u4e00\u4e2a\u91cd\u8981\u7a81\u7834\uff0c\u65e8\u5728\u901a\u8fc7\u6fc0\u6d3b\u673a\u4f53\u7684\u514d\u75ab\u7cfb\u7edf\u6765\u653b\u51fb\u764c\u7ec6\u80de\u30022-PI\u4f5c\u4e3a\u4e00\u79cd\u5f3a\u5927\u7684\u514d\u75ab\u8c03\u8282\u5242\uff0c\u5177\u6709\u6fc0\u6d3b\u5148\u5929\u514d\u75ab\u7cfb\u7edf\u548c\u8c03\u8282\u9002\u5e94\u6027\u514d\u75ab\u53cd\u5e94\u7684\u53cc\u91cd\u529f\u80fd\uff0c\u56e0\u6b64\u5728\u764c\u75c7\u514d\u75ab\u7597\u6cd5\u4e2d\u5177\u6709\u5de8\u5927\u7684\u5e94\u7528\u6f5c\u529b\u3002<\/p>\n

      1.1 \u589e\u5f3a\u80bf\u7624\u75ab\u82d7\u7684\u514d\u75ab\u539f\u6027<\/strong><\/h5>\n

      \u80bf\u7624\u75ab\u82d7\u662f\u901a\u8fc7\u5f15\u5165\u80bf\u7624\u6297\u539f\u6765\u6fc0\u6d3b\u673a\u4f53\u7684\u514d\u75ab\u7cfb\u7edf\uff0c\u4ece\u800c\u7279\u5f02\u6027\u5730\u8bc6\u522b\u548c\u6740\u4f24\u764c\u7ec6\u80de\u3002\u7136\u800c\uff0c\u7531\u4e8e\u80bf\u7624\u6297\u539f\u7684\u514d\u75ab\u539f\u6027\u8f83\u5f31\uff0c\u4f20\u7edf\u7684\u80bf\u7624\u75ab\u82d7\u5f80\u5f80\u96be\u4ee5\u4ea7\u751f\u8db3\u591f\u7684\u514d\u75ab\u53cd\u5e94\u30022-PI\u4f5c\u4e3a\u4f50\u5242\uff0c\u80fd\u591f\u663e\u8457\u589e\u5f3a\u80bf\u7624\u75ab\u82d7\u7684\u514d\u75ab\u539f\u6027\uff0c\u4fc3\u8fdb\u6297\u539f\u63d0\u5448\u7ec6\u80de\uff08APCs\uff09\u7684\u6210\u719f\u548c\u6297\u539f\u63d0\u5448\uff0c\u589e\u52a0T\u7ec6\u80de\u7684\u6d3b\u5316\u548c\u589e\u6b96\u3002\u7814\u7a76\u8868\u660e\uff0c2-PI\u80fd\u591f\u663e\u8457\u63d0\u9ad8\u80bf\u7624\u75ab\u82d7\u7684\u7597\u6548\uff0c\u5ef6\u957f\u60a3\u8005\u7684\u751f\u5b58\u671f\uff0c\u51cf\u5c11\u80bf\u7624\u590d\u53d1\u7684\u98ce\u9669\u3002<\/p>\n

      1.2 \u8054\u5408\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242<\/strong><\/h5>\n

      \u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\uff08\u5982PD-1\/PD-L1\u6291\u5236\u5242\uff09\u662f\u76ee\u524d\u764c\u75c7\u514d\u75ab\u7597\u6cd5\u4e2d\u7684\u4e00\u7c7b\u91cd\u8981\u836f\u7269\uff0c\u80fd\u591f\u963b\u65ad\u764c\u7ec6\u80de\u5bf9\u514d\u75ab\u7cfb\u7edf\u7684\u6291\u5236\u4f5c\u7528\uff0c\u6062\u590dT\u7ec6\u80de\u7684\u6297\u80bf\u7624\u6d3b\u6027\u3002\u7136\u800c\uff0c\u5355\u72ec\u4f7f\u7528\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u7684\u6548\u679c\u6709\u9650\uff0c\u90e8\u5206\u60a3\u8005\u5bf9\u5176\u4e0d\u654f\u611f\u30022-PI\u53ef\u4ee5\u901a\u8fc7\u6fc0\u6d3b\u5148\u5929\u514d\u75ab\u7cfb\u7edf\uff0c\u589e\u5f3aT\u7ec6\u80de\u7684\u6d3b\u5316\u548c\u589e\u6b96\uff0c\u4e0e\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u5f62\u6210\u534f\u540c\u6548\u5e94\uff0c\u8fdb\u4e00\u6b65\u63d0\u9ad8\u6cbb\u7597\u6548\u679c\u3002\u7814\u7a76\u8868\u660e\uff0c2-PI\u4e0ePD-1\u6291\u5236\u5242\u8054\u7528\uff0c\u80fd\u591f\u663e\u8457\u63d0\u9ad8\u5c0f\u9f20\u6a21\u578b\u4e2d\u7684\u80bf\u7624\u6d88\u9000\u7387\uff0c\u5ef6\u957f\u751f\u5b58\u671f\uff0c\u663e\u793a\u51fa\u826f\u597d\u7684\u4e34\u5e8a\u5e94\u7528\u524d\u666f\u3002<\/p>\n

      2. \u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5<\/strong><\/h4>\n

      \u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u662f\u7531\u4e8e\u673a\u4f53\u514d\u75ab\u7cfb\u7edf\u9519\u8bef\u5730\u653b\u51fb\u81ea\u8eab\u7ec4\u7ec7\u800c\u5bfc\u81f4\u7684\u4e00\u7c7b\u75be\u75c5\uff0c\u5982\u7c7b\u98ce\u6e7f\u5173\u8282\u708e\u3001\u7cfb\u7edf\u6027\u7ea2\u6591\u72fc\u75ae\u7b49\u3002\u4f20\u7edf\u7684\u6cbb\u7597\u65b9\u6cd5\u4e3b\u8981\u4f9d\u8d56\u4e8e\u514d\u75ab\u6291\u5236\u5242\uff0c\u4f46\u8fd9\u4e9b\u836f\u7269\u5f80\u5f80\u4f1a\u6291\u5236\u6574\u4e2a\u514d\u75ab\u7cfb\u7edf\uff0c\u5bfc\u81f4\u60a3\u8005\u5bb9\u6613\u611f\u67d3\u5176\u4ed6\u75be\u75c5\u30022-PI\u4f5c\u4e3a\u4e00\u79cd\u9009\u62e9\u6027\u7684\u514d\u75ab\u8c03\u8282\u5242\uff0c\u80fd\u591f\u5728\u4e0d\u5f71\u54cd\u6b63\u5e38\u514d\u75ab\u529f\u80fd\u7684\u524d\u63d0\u4e0b\uff0c\u8c03\u8282\u5f02\u5e38\u7684\u514d\u75ab\u53cd\u5e94\uff0c\u5177\u6709\u6cbb\u7597\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u7684\u6f5c\u529b\u3002<\/p>\n

      2.1 \u8c03\u8282\u514d\u75ab\u5e73\u8861<\/strong><\/h5>\n

      2-PI\u80fd\u591f\u901a\u8fc7\u6fc0\u6d3bTLRs\u3001\u4fc3\u8fdbDCs\u6210\u719f\u7b49\u65b9\u5f0f\uff0c\u8c03\u8282\u514d\u75ab\u7ec6\u80de\u7684\u529f\u80fd\uff0c\u6062\u590d\u673a\u4f53\u7684\u514d\u75ab\u5e73\u8861\u3002\u7814\u7a76\u8868\u660e\uff0c2-PI\u80fd\u591f\u6291\u5236Th17\u7ec6\u80de\u7684\u8fc7\u5ea6\u6d3b\u5316\uff0c\u51cf\u5c11\u4fc3\u708e\u56e0\u5b50\u7684\u5206\u6ccc\uff0c\u540c\u65f6\u4fc3\u8fdb\u8c03\u8282\u6027T\u7ec6\u80de\uff08Tregs\uff09\u7684\u589e\u6b96\uff0c\u589e\u5f3a\u514d\u75ab\u8010\u53d7\u3002\u8fd9\u4e9b\u4f5c\u7528\u6709\u52a9\u4e8e\u7f13\u89e3\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u7684\u75c7\u72b6\uff0c\u51cf\u5c11\u708e\u75c7\u53cd\u5e94\uff0c\u6539\u5584\u60a3\u8005\u7684\u9884\u540e\u3002<\/p>\n

      2.2 \u9776\u5411\u6cbb\u7597<\/strong><\/h5>\n

      2-PI\u8fd8\u53ef\u4ee5\u4e0e\u5176\u4ed6\u9776\u5411\u836f\u7269\u8054\u5408\u4f7f\u7528\uff0c\u5b9e\u73b0\u5bf9\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u7684\u7cbe\u51c6\u6cbb\u7597\u3002\u4f8b\u5982\uff0c2-PI\u53ef\u4ee5\u4e0e\u6297TNF-\u03b1\u5355\u514b\u9686\u6297\u4f53\u8054\u7528\uff0c\u7279\u5f02\u6027\u5730\u6291\u5236TNF-\u03b1\u4ecb\u5bfc\u7684\u708e\u75c7\u53cd\u5e94\uff0c\u51cf\u5c11\u5173\u8282\u708e\u60a3\u8005\u7684\u75bc\u75db\u548c\u80bf\u80c0\u3002\u6b64\u5916\uff0c2-PI\u8fd8\u53ef\u4ee5\u4e0eJAK\u6291\u5236\u5242\u8054\u7528\uff0c\u6291\u5236JAK-STAT\u4fe1\u53f7\u901a\u8def\uff0c\u51cf\u5c11\u81ea\u8eab\u53cd\u5e94\u6027T\u7ec6\u80de\u7684\u6d3b\u5316\uff0c\u4ece\u800c\u8fbe\u5230\u66f4\u597d\u7684\u6cbb\u7597\u6548\u679c\u3002<\/p>\n

      3. \u4e2a\u6027\u5316\u75ab\u82d7<\/strong><\/h4>\n

      \u4e2a\u6027\u5316\u75ab\u82d7\u662f\u6839\u636e\u4e2a\u4f53\u7684\u57fa\u56e0\u7279\u5f81\u548c\u75be\u75c5\u60c5\u51b5\u5b9a\u5236\u7684\u75ab\u82d7\uff0c\u80fd\u591f\u63d0\u4f9b\u66f4\u52a0\u7cbe\u51c6\u7684\u514d\u75ab\u4fdd\u62a4\u30022-PI\u4f5c\u4e3a\u4e00\u79cd\u591a\u529f\u80fd\u7684\u514d\u75ab\u8c03\u8282\u5242\uff0c\u80fd\u591f\u4e0e\u591a\u79cd\u6297\u539f\u7ed3\u5408\uff0c\u9002\u7528\u4e8e\u4e0d\u540c\u7c7b\u578b\u7684\u4e2a\u6027\u5316\u75ab\u82d7\u7684\u5f00\u53d1\u3002<\/p>\n

      3.1 \u80bf\u7624\u4e2a\u6027\u5316\u75ab\u82d7<\/strong><\/h5>\n

      \u80bf\u7624\u4e2a\u6027\u5316\u75ab\u82d7\u662f\u6839\u636e\u60a3\u8005\u7684\u80bf\u7624\u7a81\u53d8\u7279\u5f81\u5b9a\u5236\u7684\u75ab\u82d7\uff0c\u80fd\u591f\u7279\u5f02\u6027\u5730\u8bc6\u522b\u548c\u653b\u51fb\u764c\u7ec6\u80de\u30022-PI\u4f5c\u4e3a\u4f50\u5242\uff0c\u80fd\u591f\u663e\u8457\u589e\u5f3a\u80bf\u7624\u4e2a\u6027\u5316\u75ab\u82d7\u7684\u514d\u75ab\u539f\u6027\uff0c\u4fc3\u8fdbT\u7ec6\u80de\u5bf9\u80bf\u7624\u6297\u539f\u7684\u8bc6\u522b\u548c\u6740\u4f24\u3002\u7814\u7a76\u8868\u660e\uff0c2-PI\u80fd\u591f\u63d0\u9ad8\u80bf\u7624\u4e2a\u6027\u5316\u75ab\u82d7\u7684\u7597\u6548\uff0c\u5ef6\u957f\u60a3\u8005\u7684\u751f\u5b58\u671f\uff0c\u51cf\u5c11\u80bf\u7624\u590d\u53d1\u7684\u98ce\u9669\u3002<\/p>\n

      3.2 \u611f\u67d3\u6027\u75be\u75c5\u4e2a\u6027\u5316\u75ab\u82d7<\/strong><\/h5>\n

      \u5bf9\u4e8e\u67d0\u4e9b\u611f\u67d3\u6027\u75be\u75c5\uff0c\u5982HIV\u3001\u759f\u75be\u7b49\uff0c\u4f20\u7edf\u7684\u75ab\u82d7\u7b56\u7565\u96be\u4ee5\u63d0\u4f9b\u8db3\u591f\u7684\u4fdd\u62a4\u30022-PI\u53ef\u4ee5\u4e0e\u65b0\u578b\u6297\u539f\u9012\u9001\u7cfb\u7edf\uff08\u5982mRNA\u3001DNA\u75ab\u82d7\uff09\u7ed3\u5408\uff0c\u5f00\u53d1\u4e2a\u6027\u5316\u7684\u611f\u67d3\u6027\u75be\u75c5\u75ab\u82d7\u30022-PI\u80fd\u591f\u589e\u5f3a\u6297\u539f\u7684\u9012\u9001\u548c\u8868\u8fbe\uff0c\u4fc3\u8fdb\u514d\u75ab\u7ec6\u80de\u7684\u6d3b\u5316\u548c\u589e\u6b96\uff0c\u4ece\u800c\u63d0\u9ad8\u75ab\u82d7\u7684\u514d\u75ab\u539f\u6027\u548c\u4fdd\u62a4\u6548\u529b\u3002\u6b64\u5916\uff0c2-PI\u8fd8\u53ef\u4ee5\u6839\u636e\u4e2a\u4f53\u7684\u514d\u75ab\u72b6\u6001\u8fdb\u884c\u4e2a\u6027\u5316\u8c03\u6574\uff0c\u786e\u4fdd\u6bcf\u4e2a\u60a3\u8005\u90fd\u80fd\u83b7\u5f97\u4f73\u7684\u514d\u75ab\u4fdd\u62a4\u3002<\/p>\n

      4. \u6539\u8fdb\u4f50\u5242\u914d\u65b9<\/strong><\/h4>\n

      \u5c3d\u7ba12-PI\u5df2\u7ecf\u5728\u591a\u79cd\u75ab\u82d7\u4e2d\u5c55\u73b0\u51fa\u4f18\u5f02\u7684\u6027\u80fd\uff0c\u4f46\u7814\u7a76\u4eba\u5458\u4ecd\u5728\u4e0d\u65ad\u63a2\u7d22\u5982\u4f55\u8fdb\u4e00\u6b65\u4f18\u5316\u5176\u914d\u65b9\uff0c\u4ee5\u63d0\u9ad8\u5176\u514d\u75ab\u589e\u5f3a\u6548\u679c\u548c\u5b89\u5168\u6027\u3002<\/p>\n

      4.1 \u7eb3\u7c73\u4f50\u5242<\/strong><\/h5>\n

      \u7eb3\u7c73\u6280\u672f\u7684\u53d1\u5c55\u4e3a\u4f50\u5242\u7684\u6539\u8fdb\u63d0\u4f9b\u4e86\u65b0\u7684\u601d\u8def\u3002\u7814\u7a76\u4eba\u5458\u6b63\u5728\u5c1d\u8bd5\u5c062-PI\u5c01\u88c5\u5728\u7eb3\u7c73\u9897\u7c92\u4e2d\uff0c\u5f62\u6210\u7eb3\u7c73\u4f50\u5242\u3002\u7eb3\u7c73\u4f50\u5242\u4e0d\u4ec5\u53ef\u4ee5\u63d0\u9ad82-PI\u7684\u7a33\u5b9a\u6027\uff0c\u8fd8\u80fd\u5ef6\u957f\u5176\u5728\u4f53\u5185\u7684\u91ca\u653e\u65f6\u95f4\uff0c\u589e\u5f3a\u514d\u75ab\u53cd\u5e94\u7684\u6301\u4e45\u6027\u3002\u7814\u7a76\u8868\u660e\uff0c\u7eb3\u7c73\u4f50\u5242\u80fd\u591f\u663e\u8457\u63d0\u9ad82-PI\u7684\u514d\u75ab\u589e\u5f3a\u6548\u679c\uff0c\u51cf\u5c11\u4e0d\u826f\u53cd\u5e94\u7684\u53d1\u751f\uff0c\u663e\u793a\u51fa\u826f\u597d\u7684\u5e94\u7528\u524d\u666f\u3002<\/p>\n

      4.2 \u7ec4\u5408\u4f50\u5242<\/strong><\/h5>\n

      \u5355\u4e00\u4f50\u5242\u5f80\u5f80\u96be\u4ee5\u6ee1\u8db3\u6240\u6709\u75ab\u82d7\u7684\u9700\u6c42\uff0c\u56e0\u6b64\u7814\u7a76\u4eba\u5458\u6b63\u5728\u63a2\u7d22\u5c062-PI\u4e0e\u5176\u4ed6\u4f50\u5242\uff08\u5982CpG\u5be1\u6838\u82f7\u9178\u3001TLR\u6fc0\u52a8\u5242\u7b49\uff09\u7ec4\u5408\u4f7f\u7528\uff0c\u5f62\u6210\u590d\u5408\u4f50\u5242\u3002\u590d\u5408\u4f50\u5242\u80fd\u591f\u901a\u8fc7\u591a\u79cd\u9014\u5f84\u534f\u540c\u4f5c\u7528\uff0c\u589e\u5f3a\u514d\u75ab\u53cd\u5e94\u7684\u5f3a\u5ea6\u548c\u591a\u6837\u6027\u3002\u7814\u7a76\u8868\u660e\uff0c2-PI\u4e0eCpG\u5be1\u6838\u82f7\u9178\u8054\u7528\uff0c\u80fd\u591f\u663e\u8457\u63d0\u9ad8mRNA\u75ab\u82d7\u7684\u514d\u75ab\u539f\u6027\uff0c\u5ef6\u957f\u6297\u4f53\u7684\u534a\u8870\u671f\uff0c\u663e\u793a\u51fa\u826f\u597d\u7684\u4e34\u5e8a\u5e94\u7528\u6f5c\u529b\u3002<\/p>\n

      \u7ed3\u8bed<\/h3>\n

      2-\u4e19\u57fa\u54aa\u5511\u4f5c\u4e3a\u4e00\u79cd\u65b0\u578b\u7684\u6709\u673a\u5316\u5408\u7269\u4f50\u5242\uff0c\u5728\u75ab\u82d7\u7814\u53d1\u9886\u57df\u5c55\u73b0\u51fa\u4e86\u5de8\u5927\u7684\u6f5c\u529b\u3002\u5b83\u4e0d\u4ec5\u80fd\u591f\u663e\u8457\u589e\u5f3a\u673a\u4f53\u7684\u514d\u75ab\u53cd\u5e94\uff0c\u63d0\u5347\u75ab\u82d7\u7684\u4fdd\u62a4\u6548\u529b\uff0c\u8fd8\u80fd\u51cf\u5c11\u4e0d\u826f\u53cd\u5e94\u7684\u53d1\u751f\uff0c\u663e\u793a\u51fa\u826f\u597d\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u3002\u901a\u8fc7\u4e00\u7cfb\u5217\u52a8\u7269\u5b9e\u9a8c\u548c\u4eba\u4f53\u4e34\u5e8a\u8bd5\u9a8c\uff0c2-PI\u5df2\u7ecf\u8bc1\u660e\u4e86\u5176\u5728\u591a\u79cd\u75ab\u82d7\u4e2d\u7684\u5e7f\u6cdb\u5e94\u7528\u524d\u666f\u3002<\/p>\n

      \u672a\u6765\uff0c\u968f\u7740\u7814\u7a76\u7684\u6df1\u5165\u548c\u6280\u672f\u7684\u8fdb\u6b65\uff0c2-PI\u6709\u671b\u5728\u764c\u75c7\u514d\u75ab\u7597\u6cd5\u3001\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u6cbb\u7597\u3001\u4e2a\u6027\u5316\u75ab\u82d7\u7b49\u9886\u57df\u53d1\u6325\u66f4\u91cd\u8981\u7684\u4f5c\u7528\u3002\u7814\u7a76\u4eba\u5458\u5c06\u7ee7\u7eed\u63a2\u7d222-PI\u7684\u591a\u79cd\u5e94\u7528\uff0c\u4f18\u5316\u5176\u914d\u65b9\uff0c\u62d3\u5c55\u5176\u5e94\u7528\u8303\u56f4\uff0c\u4e3a\u4eba\u7c7b\u5065\u5eb7\u4e8b\u4e1a\u505a\u51fa\u66f4\u5927\u7684\u8d21\u732e\u3002\u6211\u4eec\u6709\u7406\u7531\u76f8\u4fe1\uff0c2-\u4e19\u57fa\u54aa\u5511\u5c06\u6210\u4e3a\u4e0b\u4e00\u4ee3\u75ab\u82d7\u4f50\u5242\u7684\u4ee3\u8868\uff0c\u5f15\u9886\u75ab\u82d7\u7814\u53d1\u8fdb\u5165\u4e00\u4e2a\u5168\u65b0\u7684\u65f6\u4ee3\u3002<\/p>\n

      \u6269\u5c55\u9605\u8bfb:https:\/\/www.bdmaee.net\/n-formylmorpholine-cas4394-85-8-4-formylmorpholine\/<\/a><\/br>
      \u6269\u5c55\u9605\u8bfb:      https:\/\/www.newtopchem.com\/archives\/39954<\/a><\/br>
      \u6269\u5c55\u9605\u8bfb:      https:\/\/www.newtopchem.com\/archives\/931<\/a><\/br>
      \u6269\u5c55\u9605\u8bfb:      https:\/\/www.bdmaee.net\/wp-content\/uploads\/2022\/08\/77.jpg<\/a><\/br>
      \u6269\u5c55\u9605\u8bfb:      https:\/\/www.bdmaee.net\/wp-content\/uploads\/2022\/08\/-DC5LE-reaction-type-delayed-catalyst-reaction-type-catalyst.pdf<\/a><\/br>
      \u6269\u5c55\u9605\u8bfb:      https:\/\/www.bdmaee.net\/24-pyridinedicarboxylic-acid\/<\/a><\/br>
      \u6269\u5c55\u9605\u8bfb:      https:\/\/www.cyclohexylamine.net\/category\/product\/page\/19\/<\/a><\/br>
      \u6269\u5c55\u9605\u8bfb:      https:\/\/www.newtopchem.com\/archives\/1031<\/a><\/br>
      \u6269\u5c55\u9605\u8bfb:      https:\/\/www.newtopchem.com\/archives\/44845<\/a><\/br>
      \u6269\u5c55\u9605\u8bfb:      https:\/\/www.cyclohexylamine.net\/lupragen-n105-pc-cat-nmm-dabco-nmm\/<\/a><\/br><\/p>\n","protected":false},"excerpt":{"rendered":"

      2-\u4e19\u57fa\u54aa\u5511\uff1a\u65b0\u578b\u75ab\u82d7\u4f50\u5242\u7684\u660e\u661f\u6210\u5206 \u5728\u5f53\u4eca\u5168\u7403\u516c\u5171\u536b\u751f\u9886\u57df\uff0c\u75ab\u82d7\u7684\u7814\u53d1\u548c\u5e94\u7528\u65e0\u7591\u662f\u5e94\u5bf9\u5404\u79cd\u4f20\u67d3\u75c5\u7684\u5173\u952e\u624b\u6bb5\u4e4b\u4e00\u3002\u7136\u800c\uff0c\u968f\u7740\u4eba\u4eec\u5bf9\u75ab\u82d7\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u7684\u8981\u6c42\u8d8a\u6765\u8d8a\u9ad8\uff0c\u4f20\u7edf\u75ab\u82d7\u4f50\u5242\u5df2\u7ecf\u96be\u4ee5\u6ee1\u8db3\u73b0\u4ee3\u533b\u5b66\u7684\u9700\u6c42\u3002\u4e3a\u4e86\u63d0\u9ad8\u75ab\u82d7\u7684\u514d\u75ab\u539f\u6027\uff0c\u79d1\u5b66\u5bb6\u4eec\u4e0d\u65ad\u63a2\u7d22\u65b0\u7684\u4f50\u5242\u6750\u6599\uff0c\u5176\u4e2d\uff0c2-\u4e19\u57fa\u54aa\u5511\uff082-Propylimidazole, 2- …<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[2401],"_links":{"self":[{"href":"https:\/\/www.xindianchem.com\/wp-json\/wp\/v2\/posts\/6378"}],"collection":[{"href":"https:\/\/www.xindianchem.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.xindianchem.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.xindianchem.com\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.xindianchem.com\/wp-json\/wp\/v2\/comments?post=6378"}],"version-history":[{"count":0,"href":"https:\/\/www.xindianchem.com\/wp-json\/wp\/v2\/posts\/6378\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.xindianchem.com\/wp-json\/wp\/v2\/media?parent=6378"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.xindianchem.com\/wp-json\/wp\/v2\/categories?post=6378"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.xindianchem.com\/wp-json\/wp\/v2\/tags?post=6378"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}